I have thumb pain issues particularly upon waking in the morning. The cream has helped tremendously with that thumb pain. I just rub it into each hand first thing in the morning when my thumbs are stiff and painful. The cream helps A LOT with that arthritis pain and I’m able to avoid taking any other pain medication. Combined with the oil under the tongue which I take twice per day I can remain nearly pain free now. I’ve noticed the results got even better over time as the CBD built up in my body.